Diplomatic relations between Switzerland and the Dominican Republic are harmonious. The economic and trade exchanges are not particularly well developed, but offer a growth potential. The Dominican Republic is well known to many Swiss as a holiday destination.

The Dominican Republic is a tourism and emigration destination for many Swiss. Air transport and the protection of investments are covered by bilateral agreements. As of 1 May 2011, the regional consular centre in Santo Domingo has also been responsible for consular affairs in Haiti, Antigua and Barbuda, Dominica, St. Kitts and Nevis.

At the end of 2012, there were 2060 Swiss living in the Dominican Republic, making it the largest Swiss colony in the Caribbean.

The Dominican Republic became independent in 1884. Switzerland recognised the new state and opened a Consulate in Santo Domingo in 1936. During the Second World War, Switzerland looked after the interests of the Dominican Republic in various countries. In 1959, the Consulate was upgraded to a Consulate General and in 2007, an Embassy was opened. As of 01.05.2011, the consular hub in Santo Domingo also has responsibility for consular affairs in Haiti. 

Trade relations go back to the 19th century when Swiss companies extracted guano, an organic fertiliser, and purchased cocoa beans.